Porphyrin Profil
Porphyrine werden im Rahmen der Blutsynthese als Zwischenprodukte gebildet. Diese werden in einem bestimmten Muster auch im Urin ausgeschieden. Veränderungen in diesem Muster erlauben Rückschlüsse auf Belastungen u.a. mit Schwermetalle und organischen Toxinen. Informiert über:
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Referenzen
1) Fowler BA, Porphyrinurias induced by mercury and other metals, Toxicol Sci 61(2):197-8,2001.
2) Pingree SD, Simmonds PL, Rummel KT, Woods JS, Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats,Toxicol Sci [61(2):234-40,2001.
3) Apostoli M, Sarnico M, Bavazzano P, Bartoli D, Arsenic and porphyrins, American Journal of Industrial Medicine 42:180-187 ,2002.
4) A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production., Toxicol Lett ,2005.
5) The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans. Toxicol Appl Pharmacol , 206(2):113-20, 2005.
6) Validity of spot urine samples as a surrogate measure of 24-hour porphyrin excretion rates. Evaluation of diurnal variations in porphyrin, mercury, and creatinine concentrations among subjects with very low occupational mercury exposure. J Occup Environ Med , 40(12):1090-101, 1999.
7) The validity of spot urine samples for low-level occupational mercury exposure assessment and relationship to porphyrin and creatinine excretion rates. J Pharmacol Exp Ther 277(1):239-44, 1996.
8), Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity. Can J Physiol Pharmacol 74(2):210-5, 1997.
9) Behavioral effects of low-level exposure to elemental Hg among dentists.Neurotoxicol Teratol 17(2):161-8, 1995.
10) Nataf R, Skorupka C, Amet L, Lam A, Springbett A, Lathe R, Porphyrinuria in childhood autistic disorder. Toxicol Appl Pharmacol (in press)
Concerns About The Use Of Porphyrins Testing For Heavy metals Assessment